TWYNEO® (tretinoin and benzoyl peroxide) Cream, 0.1%/3%

Twyneo is a prescription gel used to treat acne in people 9 years and older.

It combines benzoyl peroxide to kill bacteria and tretinoin to unclog pores, helping clear acne with less irritation.

Apply it once daily to clean, dry skin or as directed by your prescriber.

You may start seeing improvement in 4 to 8 weeks, with best results after consistent use.

Common side effects include dryness, redness, and peeling. These are usually mild and improve over time.

Yes. Let the gel fully absorb before applying non-comedogenic (non-pore-clogging) makeup.

Avoid excessive sun exposure, harsh skincare products, and applying Twyneo near the eyes, mouth, or broken skin.

You may experience dryness, redness, peeling, or a mild burning sensation. These usually improve as your skin adjusts.

It’s designed to reduce irritation, but if you have sensitive skin, use it as directed and talk to your provider if irritation continues.

Avoid using other topical retinoids or acne treatments on the same area unless your doctor advises it.

Yes. A gentle, non-comedogenic moisturizer can help reduce dryness or irritation during treatment.

It might—use white towels and be careful with clothing and bedding.